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1

HCN-related channelopathies

Mirko Baruscotti, Georgia Bottelli, Raffaella Milanesi, Jacopo C. DiFrancesco, Dario DiFrancesco

Journal:

Pflügers Archiv European Journal of Physiology

Year:

2010

Language:

english

File:

PDF, 508 KB

english, 2010

2

Kinetic and ionic properties of the human HCN2 pacemaker channel

Anna Moroni, Andrea Barbuti, Claudia Altomare, Carlo Viscomi, Julie Morgan, Mirko Baruscotti, Dario DiFrancesco

Journal:

Pflügers Archiv European Journal of Physiology

Year:

2000

Language:

english

File:

PDF, 116 KB

english, 2000

3

Single-channel properties of the sinoatrial node Na+current in the newborn rabbit

Mirko Baruscotti, Dario DiFrancesco, Richard B. Robinson

Journal:

Pflügers Archiv European Journal of Physiology

Year:

2001

Language:

english

File:

PDF, 80 KB

english, 2001

4

Activation of f-channels by cAMP analogues in macropatches from rabbit sino-atrial node myocytes

P. Bois, B. Renaudon, M. Baruscotti, J. Lenfant, D. DiFrancesco

Journal:

The Journal of Physiology

Year:

1997

Language:

english

File:

PDF, 235 KB

english, 1997

5

Action of internal pronase on the f-channel kinetics in the rabbit SA node

A. Barbuti, M. Baruscotti, C. Altomare, A. Moroni, D. DiFrancesco

Journal:

The Journal of Physiology

Year:

1999

Language:

english

File:

PDF, 185 KB

english, 1999

6

The Pacemaker Current: From Basics to the Clinics

ANDREA BARBUTI, MIRKO BARUSCOTTI, DARIO DIFRANCESCO

Journal:

Journal of Cardiovascular Electrophysiology

Year:

2007

Language:

english

File:

PDF, 120 KB

english, 2007

7

Effects of dronedarone on Acetylcholine-activated current in rabbit SAN cells

Claudia Altomare, Andrea Barbuti, Carlo Viscomi, Mirko Baruscotti, Dario DiFrancesco

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 140 KB

english, 2000

8

Direct inhibition of the pacemaker (If) current in rabbit sinoatrial node cells by genistein

Claudia Altomare, Agnese Tognati, Jocelyn Bescond, Arnaldo Ferroni, Mirko Baruscotti

Journal:

British Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 614 KB

english, 2006

9

Heteromeric HCN1–HCN4 Channels: A Comparison with Native Pacemaker Channels from the Rabbit Sinoatrial Node

Claudia Altomare, Benedetta Terragni, Chiara Brioschi, Raffaella Milanesi, Cinzia Pagliuca, Carlo Viscomi, Anna Moroni, Mirko Baruscotti, Dario DiFrancesco

Journal:

The Journal of Physiology

Year:

2003

Language:

english

File:

PDF, 391 KB

english, 2003

10

Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels

A. Bucchi, A. Tognati, R. Milanesi, M. Baruscotti, D. DiFrancesco

Journal:

The Journal of Physiology

Year:

2006

Language:

english

File:

PDF, 238 KB

english, 2006

11

Pacemaker Channels

MIRKO BARUSCOTTI, DARIO DIFRANCESCO

Journal:

Annals of the New York Academy of Sciences

Year:

2004

File:

PDF, 3.46 MB

2004

12

Physiology and pharmacology of the cardiac pacemaker (“funny”) current

Mirko Baruscotti, Annalisa Bucchi, Dario DiFrancesco

Journal:

Pharmacology & Therapeutics

Year:

2005

Language:

english

File:

PDF, 1.08 MB

english, 2005

13

Multinucleated giant cells with an osteoclast phenotype derived from caprine peripheral blood mononuclear cells

Giuliano Pisoni, Patrizia D’Amelio, Francesca Sassi, Giovanni Manarolla, Licia Scaccabarozzi, Clara Locatelli, Nausicaa Mazzocchi, Mirko Baruscotti, Dario DiFrancesco, Paolo Moroni

Journal:

The Veterinary Journal

Year:

2011

Language:

english

File:

PDF, 584 KB

english, 2011

14

Heart rate reduction via selective ‘funny’ channel blockers

Annalisa Bucchi, Andrea Barbuti, Mirko Baruscotti, Dario DiFrancesco

Journal:

Current Opinion in Pharmacology

Year:

2007

Language:

english

File:

PDF, 311 KB

english, 2007

15

Autonomic rate modulation in san cells involves changes in diastolic depolarization and the i(f) current

Mirko Baruscotti, Annalisa Bucchi, Richard B. Robinson, Dario DiFrancesco

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2007

Language:

english

File:

PDF, 54 KB

english, 2007

16

Modulation of rate by autonomic agonists in SAN cells involves changes in diastolic depolarization and the pacemaker current

Annalisa Bucchi, Mirko Baruscotti, Richard B. Robinson, Dario DiFrancesco

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2007

Language:

english

File:

PDF, 884 KB

english, 2007

17

Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells

Andrea Barbuti, Alessia Crespi, Daniela Capilupo, Nausicaa Mazzocchi, Mirko Baruscotti, Dario DiFrancesco

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2009

Language:

english

File:

PDF, 1.39 MB

english, 2009

18

Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node

Chiara Brioschi, Stefano Micheloni, James O. Tellez, Giuliano Pisoni, Renato Longhi, Paolo Moroni, Rudi Billeter, Andrea Barbuti, Halina Dobrzynski, Mark R. Boyett, Dario DiFrancesco, Mirko Baruscotti

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2009

Language:

english

File:

PDF, 1.36 MB

english, 2009

19

The cardiac pacemaker current

Mirko Baruscotti, Andrea Barbuti, Annalisa Bucchi

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2010

Language:

english

File:

PDF, 596 KB

english, 2010

20

Mesoangioblasts from ventricular vessels can differentiate in vitro into cardiac myocytes with sinoatrial-like properties

Andrea Barbuti, Beatriz G. Galvez, Alessia Crespi, Angela Scavone, Mirko Baruscotti, Chiara Brioschi, Giulio Cossu, Dario DiFrancesco

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2010

Language:

english

File:

PDF, 1.14 MB

english, 2010

21

A caveolin-binding domain in the HCN4 channels mediates functional interaction with caveolin proteins

Andrea Barbuti, Angela Scavone, Nausicaa Mazzocchi, Benedetta Terragni, Mirko Baruscotti, Dario DiFrancesco

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2012

Language:

english

File:

PDF, 1.17 MB

english, 2012

22

If-dependent modulation of pacemaker rate mediated by cAMP in the presence of ryanodine in rabbit sino-atrial node cells

Annalisa Bucchi, Mirko Baruscotti, Richard B. Robinson, Dario DiFrancesco

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2003

Language:

english

File:

PDF, 224 KB

english, 2003

23

Clinical Efficacy of Ivabradine in Patients With Inappropriate Sinus Tachycardia: A Prospective, Randomized, Placebo-Controlled, Double-Blind, Crossover Evaluation

Riccardo Cappato, Serenella Castelvecchio, Cristian Ricci, Elisabetta Bianco, Laura Vitali-Serdoz, Tomaso Gnecchi-Ruscone, Mario Pittalis, Luigi De Ambroggi, Mirko Baruscotti, Maddalena Gaeta, Frances

Journal:

Journal of the American College of Cardiology

Year:

2012

Language:

english

File:

PDF, 879 KB

english, 2012

24

Adenovirus-mediated expression of 5-HT1B receptors in cardiac ventricle myocytes; coupling to inwardly rectifying K+ channels

Afshin Ghavami, Mirko Baruscotti, Richard B Robinson, René Hen

Journal:

European Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 507 KB

english, 1997

25

How “Funny” is the Cardiac Pacemaking? a Quantitative Analysis Based on Dynamic Clamp Recordings

Ravagli, Enrico, Bucchi, Annalisa, Bartolucci, Chiara, Baruscotti, Mirko, DiFrancesco, Dario, Severi, Stefano

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 46 KB

english, 2014

26

Molecular Architecture of the Human Sinus Node: Insights Into the Function of the Cardiac Pacemaker

Chandler, N. J., Greener, I. D., Tellez, J. O., Inada, S., Musa, H., Molenaar, P., DiFrancesco, D., Baruscotti, M., Longhi, R., Anderson, R. H., Billeter, R., Sharma, V., Sigg, D. C., Boyett, M. R., D

Journal:

Year:

2009

Language:

english

File:

PDF, 16.33 MB

english, 2009

27

GW25-e4591 Electrophysiological study of the mechanism of action of the Traditional Chinese Medicine compound TMYX on the spontaneous activity of cardiac pacemaker cells

Manuel, Paina, Yi, Wang, Annalisa, Bucchi, Andrea, Barbuti, Yan, Wang Yan, Liu, Sheng, Jin, Yang, Mirko, Baruscotti, Dario, DiFrancesco

Journal:

Journal of the American College of Cardiology

Year:

2014

Language:

english

File:

PDF, 85 KB

english, 2014

28

Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4

Baruscotti, M., Bucchi, A., Viscomi, C., Mandelli, G., Consalez, G., Gnecchi-Rusconi, T., Montano, N., Casali, K. R., Micheloni, S., Barbuti, A., DiFrancesco, D.

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 489 KB

english, 2011

29

Estradiol Stimulates Capillary Formation by Human Endothelial Progenitor Cells: Role of Estrogen Receptor- / , Heme Oxygenase 1, and Tyrosine Kinase

Baruscotti, I., Barchiesi, F., Jackson, E. K., Imthurn, B., Stiller, R., Kim, J.-H., Schaufelberger, S., Rosselli, M., Hughes, C. C. W., Dubey, R. K.

Journal:

Year:

2010

Language:

english

File:

PDF, 1.09 MB

english, 2010

30

C Terminus-mediated Control of Voltage and cAMP Gating of Hyperpolarization-activated Cyclic Nucleotide-gated Channels

Viscomi, C., Altomare, C., Bucchi, A., Camatini, E., Baruscotti, M., Moroni, A., DiFrancesco, D.

Journal:

Journal of Biological Chemistry

Year:

2001

Language:

english

File:

PDF, 587 KB

english, 2001

31

The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunction

Milanesi, Raffaella, Bucchi, Annalisa, Baruscotti, Mirko

Journal:

Journal of Interventional Cardiac Electrophysiology

Year:

2015

Language:

english

File:

PDF, 3.31 MB

english, 2015

32

Embryonic Stem Cell-Derived CD166+ Precursors Develop Into Fully Functional Sinoatrial-Like Cells

Scavone, A., Capilupo, D., Mazzocchi, N., Crespi, A., Zoia, S., Campostrini, G., Bucchi, A., Milanesi, R., Baruscotti, M., Benedetti, S., Antonini, S., Messina, G., DiFrancesco, D., Barbuti, A.

Journal:

Circulation Research

Year:

2013

Language:

english

File:

PDF, 3.63 MB

english, 2013

33

Recessive Loss-of-Function Mutation in the Pacemaker HCN2 Channel Causing Increased Neuronal Excitability in a Patient with Idiopathic Generalized Epilepsy

DiFrancesco, J. C., Barbuti, A., Milanesi, R., Coco, S., Bucchi, A., Bottelli, G., Ferrarese, C., Franceschetti, S., Terragni, B., Baruscotti, M., DiFrancesco, D.

Journal:

Journal of Neuroscience

Year:

2011

Language:

english

File:

PDF, 2.69 MB

english, 2011

34

Familial Sinus Bradycardia Associated with a Mutation in the Cardiac Pacemaker Channel

Milanesi, Raffaella, Baruscotti, Mirko, Gnecchi-Ruscone, Tomaso, DiFrancesco, Dario

Journal:

Boston Medical and Surgical Journal

Year:

2006

Language:

english

File:

PDF, 1.31 MB

english, 2006

35

Electrophysiology and pacemaker function of the developing sinoatrial node

Baruscotti, M., Robinson, R. B.

Journal:

AJP Heart and Circulatory Physiology

Year:

2007

Language:

english

File:

PDF, 738 KB

english, 2007

36

Human cord blood CD34+ progenitor cells acquire functional cardiac properties through a cell fusion process

Avitabile, D., Crespi, A., Brioschi, C., Parente, V., Toietta, G., Devanna, P., Baruscotti, M., Truffa, S., Scavone, A., Rusconi, F., Biondi, A., D'Alessandra, Y., Vigna, E., DiFrancesco, D., Pesce, M

Journal:

AJP Heart and Circulatory Physiology

Year:

2011

Language:

english

File:

PDF, 1.71 MB

english, 2011

37

Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4

Mirko Baruscotti, Annalisa Bucchi, Carlo Viscomi, Giacomo Mandelli, Giacomo Consalez, Tomaso Gnecchi-Rusconi, Nicola Montano, Karina Rabello Casali, Stefano Micheloni, Andrea Barbuti, Dario DiFrancesc

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.46 MB

english, 2011

38

A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus Tachycardia

Baruscotti, M., Bucchi, A., Milanesi, R., Paina, M., Barbuti, A., Gnecchi-Ruscone, T., Bianco, E., Vitali-Serdoz, L., Cappato, R., DiFrancesco, D.

Journal:

European Heart Journal

Year:

2015

Language:

english

File:

PDF, 879 KB

english, 2015

39

Current understanding of the pathophysiological mechanisms responsible for inappropriate sinus tachycardia: role of the If“funny” current

Baruscotti, Mirko, Bianco, Elisabetta, Bucchi, Annalisa, DiFrancesco, Dario

Journal:

Journal of Interventional Cardiac Electrophysiology

Year:

2016

Language:

english

File:

PDF, 800 KB

english, 2016

40

Cell-specific Dynamic Clamp analysis of the role of funny If current in cardiac pacemaking

Ravagli, E., Bucchi, A., Bartolucci, C., Paina, M., Baruscotti, M., DiFrancesco, D., Severi, S.

Journal:

Progress in Biophysics and Molecular Biology

Year:

2015

Language:

english

File:

PDF, 2.40 MB

english, 2015

41

[IEEE 2015 Computing in Cardiology Conference (CinC) - Nice, France (2015.9.6-2015.9.9)] 2015 Computing in Cardiology Conference (CinC) - Rate-adapted dynamic-clamp of the funny current in sinoatrial pacemaker cells

Bartolucci, Chiara, Ravagli, Enrico, Bucchi, Annalisa, Baruscotti, Mirko, DiFrancesco, Dario, Severi, Stefano

Year:

2015

Language:

english

File:

PDF, 518 KB

english, 2015

42

The newborn rabbit sino-atrial node expresses a neuronal type I-like Na+ channel.

Baruscotti, M, Westenbroek, R, Catterall, W A, DiFrancesco, D, Robinson, R B

Journal:

The Journal of Physiology

Year:

1997

Language:

english

File:

PDF, 1.82 MB

english, 1997

43

Stem Cell-Like Human Endothelial Progenitors Show Enhanced Colony-Forming Capacity After Brief Sevoflurane Exposure: Preconditioning of Angiogenic Cells by Volatile Anesthetics

Lucchinetti, Eliana, Zeisberger, Steffen M., Baruscotti, Isabella, Wacker, Johannes, Feng, Jianhua, Zaugg, Kathrin, Dubey, Raghvendra, Zisch, Andreas H., Zaugg, Michael

Journal:

Anesthesia & Analgesia

Year:

2009

Language:

english

File:

PDF, 726 KB

english, 2009

44

A TTX-sensitive inward sodium current contributes to spontaneous activity in newborn rabbit sino-atrial node cells.

Baruscotti, M, DiFrancesco, D, Robinson, R B

Journal:

The Journal of Physiology

Year:

1996

Language:

english

File:

PDF, 1.51 MB

english, 1996

45

Epigenetics in Cardiac Health and Disease225miR-218 and mi-R34a drive persistent myocardial oxidative stress by targeting chromatin remodelers DNMT3b and SIRT1: new mechanistic insights in diabetic cardiomyopathy226Effects of miRNAs modulated by endurance training on cardiomyocyte excitability227Differential transcriptome and microRNA expression signatures in the healthy heart (RV vs. LV) and the failing, pressure-overloaded right ventricle (SuHx model)

Costantino, S, Bonzanni, M, Legchenko, E, Paneni, F, Mitchell, K, Berrino, L, Schwarzwald, C, Volpe, M, Luscher, TF, Cosentino, F, Napoli, A, Landi, S, Bucchi, A, Vernillo, G, Baruscotti, M, La Torre,

Journal:

Cardiovascular Research

Year:

2016

Language:

english

File:

PDF, 32 KB

english, 2016

46

INaP selective inhibition reverts precocious inter- and motorneurons hyperexcitability in the Sod1-G93R zebrafish ALS model

Benedetti, Lorena, Ghilardi, Anna, Rottoli, Elsa, De Maglie, Marcella, Prosperi, Laura, Perego, Carla, Baruscotti, Mirko, Bucchi, Annalisa, Del Giacco, Luca, Francolini, Maura

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 3.88 MB

english, 2016

47

A Traditional Chinese Medicine Drug (TMYX) Controls Heart Rate by Modulation of the Pacemaker (F) Channels

Paina, Manuel, Piantoni, Chiara, Carnevali, Luca, Frosio, Anthony, Bucchi, Annalisa, Barbuti, Andrea, Sheng, Liu, Yanyan, Wang, Wang, Yi, DiFrancesco, Dario, Baruscotti, Mirko

Journal:

Biophysical Journal

Year:

2017

Language:

english

File:

PDF, 48 KB

english, 2017

48

HCN3 Channel Expression in Human Leukocytes

Piantoni, Chiara, Gualdoni, Angelica, Bazzini, Claudia, Milanesi, Raffaella, Adelfio, Miryam, Bucchi, Annalisa, Barbuti, Andrea, Pecchiari, Matteo, Baruscotti, Mirko, DiFrancesco, Dario

Journal:

Biophysical Journal

Year:

2017

Language:

english

File:

PDF, 49 KB

english, 2017

49

P1582Molecular basis of cardiac pacemaker ageing in mouse

Atkinson, A., Bucchi, A., Piantoni, C., Difrancesco, D., Baruscotti, M., Boyett, MR., Dobrzynski, H.

Journal:

Year:

2017

Language:

english

File:

PDF, 88 KB

english, 2017

50

The expression of the rare caveolin-3 variant T78M alters cardiac ion channels function and membrane excitability

Campostrini, Giulia, Bonzanni, Mattia, Lissoni, Alessio, Bazzini, Claudia, Milanesi, Raffaella, Vezzoli, Elena, Francolini, Maura, Baruscotti, Mirko, Bucchi, Annalisa, Rivolta, Ilaria, Fantini, Matteo

Journal:

Cardiovascular Research

Year:

2017

Language:

english

File:

PDF, 525 KB

english, 2017

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